课题组简介：

           课题组现有教师7人，教授2人，副教授2人，讲师3人。

   本课题组以水稻、大麦等作物及模式植物拟南芥等为研究对象，利用遗传学、分子生物学、细胞生物学、生物信息学等手段挖掘调控植物耐逆（非生物和生物胁迫）的关键基因，揭示其参与逆境适应的分子机制及调控网络；利用基因编辑技术进行基因聚合育种，培育具有优良性状的作物新种质。在相关研究领域形成了课题组明显的特色和优势，已取得了一些重要成果，在Nature Genetics、Nature Communications、Plant Biotechnology Journal、Plant Cell and Environment等国际著名期刊杂志发表多篇文章。

   课题组先后承担国家自然科学基金面上项目、国家自然科学基金委国际合作项目子项目、国家科技支撑计划子课题、浙江省自然科学基金一般项目和青年项目、杭州市农业与社会发展科研重点项目等多项课题。

课题组照片

课题组负责人：薛大伟

课题组成员

   教师：沈波、陈波、牟望舒、方云霞、田全祥、党聪

   学生：李佳、岑绮雯、鲍聆然、严嘉杰、周丹妮、俞彤苑、丁妞、刘叶霖、叶意辰、董梦圆、曹丹芸、李雅雯、夏婧、沈怡、平雨琛等

主要研究方向

1. 植物抗逆（盐、重金属、低温）的分子机制及调控网络

2. 作物抗病虫基因挖掘及分子调控机制

3. 作物重要农艺性状基因克隆及分子调控机制

4. 作物高产优质耐逆种质资源的创制

代表性成果：

1)  Yu T, Cen Q, Kang L, Mou W, Zhang X, Fang Y, Zhang X, Tian Q, Xue D. Identification and expression pattern analysis of the OsSnRK2 gene family in rice. Front Plant Sci. 2022 Dec 13;13:1088281. doi: 10.3389/fpls.2022.1088281. PMID: 36582638; PMCID: PMC9792972.

2)  Yan J, Fang Y, Xue D. Advances in the Genetic Basis and Molecular Mechanism of Lesion Mimic Formation in Rice. Plants (Basel). 2022 Aug 21;11(16):2169. doi: 10.3390/plants11162169. PMID: 36015472; PMCID: PMC9412831.

3)   Kang L, Teng Y, Cen Q, Fang Y, Tian Q, Zhang X, Wang H, Zhang X, Xue D. Genome-Wide Identification of R2R3-MYB Transcription Factor and Expression Analysis under Abiotic Stress in Rice. Plants (Basel). 2022 Jul 25;11(15):1928. doi: 10.3390/plants11151928. PMID: 35893632; PMCID: PMC9330779.

4)  Wen D, Bao L, Huang X, Qian X, Chen E, Shen B. OsABT Is Involved in Abscisic Acid Signaling Pathway and Salt Tolerance of Roots at the Rice Seedling Stage. Int J Mol Sci. 2022 Sep 13;23(18):10656. doi: 10.3390/ijms231810656. PMID: 36142568; PMCID: PMC9504391.

5)  Tian Q, Shen L, Luan J, Zhou Z, Guo D, Shen Y, Jing W, Zhang B, Zhang Q, Zhang W. Rice shaker potassium channel OsAKT2 positively regulates salt tolerance and grain yield by mediating K⁺ redistribution. Plant Cell Environ. 2021 Sep;44(9):2951-2965. doi: 10.1111/pce.14101. Epub 2021 May 28. PMID: 34008219.

6)  Fang Y, Zhang XQ, Tong T, Zhang Z, Zhang X, Tian B, Cui J, Zheng J, Xue D. Physiological characterization and gene mapping of a novel cuticular wax-related mutant in barley (Hordeum vulgare L.). Plant Growth Regulation, 2021, 93(2): 221-230 doi: 10.1007/s10725-020-00680-7

7)  Dang C, Zhang Y, Sun C, Li R, Wang F, Fang Q, Yao H, Stanley D, Ye G. dsRNAs Targeted to the Brown Planthopper Nilaparvata lugens: Assessing Risk to a Non-Target, Beneficial Predator, Cyrtorhinus lividipennis. J Agric Food Chem. 2022 Jan 12;70(1):373-380. doi: 10.1021/acs.jafc.1c05487. Epub 2021 Dec 30. PMID: 34967611.

8)  Dang C, Zhou X, Sun C, Wang F, Peng Y, Ye G. Impacts of Bt rice on non-target organisms assessed by the hazard quotient (HQ). Ecotoxicol Environ Saf. 2021 Jan 1;207:111214. doi: 10.1016/j.ecoenv.2020.111214. Epub 2020 Sep 2. PMID: 32890949.

9)  Mou W, Kao YT, Michard E, Simon AA, Li D, Wudick MM, Lizzio MA, Feijó JA, Chang C. Ethylene-independent signaling by the ethylene precursor ACC in Arabidopsis ovular pollen tube attraction. Nat Commun. 2020 Aug 14;11(1):4082. doi: 10.1038/s41467-020-17819-9. PMID: 32796832; PMCID: PMC7429864.

10)   Fang Y, Zhang X, Zhang X, Tong T, Zhang Z, Wu G, Hou L, Zheng J, Niu C, Li J, Wang W, Wang H and Xue D. A high-density genetic linkage map of SLAFs and QTL analysis of grain size and weight in barley (Hordeum vulgare L.). Frontiers in Plant Science, 2020, 11: 620922. doi: 10.3389/fpls.2020.620922 ISSN: 1664-462X

11)  Fang Yunxia, Hou Linlin, Zhang Xiaoqin, Pan Jiangjie, Ren Deyong, Zeng Dali, Guo Longbiao, Qian Qian, Hu Jiang, Xue Dawei. Disruption of ζ-Carotene Desaturase Protein ALE1 Leads to Chloroplast Developmental Defects and Seedling Lethality. Journal of Agricultural and Food Chemistry, 2019, 67: 11607-11615  

12)  Lu Xueli, Fang Yunxia, Tian Bin, Tong Tao, Wang Jiahui, Wang Hua, Cai Shengguan, Hu Jiang, Zeng Dali, Xu Heng, Zhang Xiaoqin, Xue Dawei. Genetic variation of HvXYN1 associated with endoxylanase activity and TAX content in barley (Hordeum vulgare L.). BMC Plant Biology, 2019, 19: 170

13)  Fang Y, Zhang X, Xue D. Genetic analysis and molecular breeding applications of malting quality QTLs in barley. Frontiers in Genetics, 2019, 10: 352

14)  Xue D, Zhang X, Lu X, Chen G, Chen Z-H. Molecular and evolutionary mechanisms of cuticular wax for plant drought tolerance. Frontiers in Plant Science 2017, 8: 621.

15)   Dang C, Lu Z, Wang L, Chang X, Wang F, Yao H, Peng Y, Stanley D, Ye G. Does Bt rice pose risks to non-target arthropods? Results of a meta-analysis in China. Plant Biotechnol J. 2017 Aug;15(8):1047-1053. doi: 10.1111/pbi.12698. Epub 2017 Feb 20. PMID: 28111920; PMCID: PMC5506656.

16)  Xue D, Jiang H, Deng X, Zhang X, Wang H, Xu X,. Hu J, Zeng D, Guo L, Qian Q. Comparative proteomic analysis provides new insights into cadmium accumulation in rice grain under cadmium stress. Journal of Hazardous Materials, 2014, 280: 269-278

17)   Jiao Y*, Wang Y*, Xue D*, Wang J , Yan M, Liu G, Dong G, Zeng D, Lu Z, Zhu X, Qian Q, Li J. Regulation of OsSPL14 by OsmiR156 defines ideal plant architecture in rice. Nature Genetics, 2010, 42: 541-544 (*Contributed equally)